• Mohammed A. Merzah Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
  • Shewaye Natae Department of Public Health, College of Medicine and Health Science, Ambo University, Ethiopia



COMT, rs4680, Val158/Met, catechol O-methyltransferase, hypertension, systolic blood pressure, diastolic blood pressure


Hypertension is a preventable risk factor of cardiovascular diseases. It is considered a major cause of CVD-morbidity and mortality worldwide. Some risk factors and prevention strategies related to hypertension were studied intensively, however, with growing the burden of this disorder and genetic has become the dominant field of treating diseases, still, specific genes involved in increasing blood pressure remain to be identified. This meta-analysis was conducted to assess the relationship of COMT Val158/Met variation to high systolic and diastolic blood pressure. PubMed and Web of Science (WOS) were intensively searched for the genetic association on the link of COMT Val158/Met to hypertension. The search was done up to October 15th 2020 and updated on November 22nd 2020. Two investigators were independently extracting data and evaluating the risk of bias using the Cochrane risk of bias tool. Q-genie tool was used to assess the quality of all included articles. Met-dominant model (Met/Met + Val/Met vs Val/Val) showed a significant association to systolic and diastolic blood pressure with a pooled standardized mean difference of -0.215 and 95%CI [-0.399 to -0.0300] and -0.205, 95%CI [-0.390 to -0.0197], respectively. Met allele was significantly related to high systolic and diastolic blood pressure. However, high-quality, case-control studies are lacking.


Mc Namara K, Alzubaidi H, Jackson JK. Cardiovascular disease as a leading cause of death: how are pharmacists getting involved?. Integr Pharm Res Pract. 2019;8:1-11. Published 2019 Feb 4. doi:10.2147/IPRP.S133088

Tsushima H, Yamamoto H, Kitagawa T, et al. Association of Epicardial and Abdominal Visceral Adipose Tissue With Coronary Atherosclerosis in Patients With a Coronary Artery Calcium Score of Zero. Circ J. 2015;79(May):1-2. doi:10.1253/circj.CJ-14-1169

Maarman GJ, Chakafana G, Sliwa K. World Heart Day: a World Heart Federation communiqué on the future of basic sciences and translational medicine in global cardiovascular research. Am J Physiol Lung Cell Mol Physiol. 2020 Sep 1;319(3):L545-L546. doi: 10.1152/ajplung.00339.2020. Epub 2020 Jul 29. PMID: 32726129.

Flora GD, Nayak MK. A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes. Curr Pharm Des. 2019;25(38):4063-4084. doi:10.2174/1381612825666190925163827

Lawes CMM, Hoorn S Vander, Rodgers A, Society I. Global burden of blood-pressure-related disease , 2001. Lancet. 2001:1513-1518.

Ondimu DO, Kikuvi GM, Otieno WN. Risk factors for hypertension among young adults (18-35) years attending in Tenwek Mission Hospital, Bomet County, Kenya in 2018. Pan Afr Med J. 2019;33(210). doi:10.11604/pamj.2019.33.210.18407

Shen Y, Chang C, Zhang J, Jiang Y, Ni B, Wang Y. Prevalence and risk factors associated with hypertension and prehypertension in a working population at high altitude in China : a cross-sectional study. Environ Health Prev Med. 2017;22(19):1-8. doi:10.1186/s12199-017-0634-7

Samadian F, Dalili N, Jamalian A. Lifestyle Modifications to Prevent and Control Hypertension Review. Iran J Kidney Dis. 2016;10(5):237-263.

Freis ED, Arias LA, Armstrong ML, Blount AW. Effects of Treatment on Morbidity in Hypertension. JAMA. 1967;202(11).

Salminen M, Jalanko ANU, Savolainen R. Cloning and Characterization of Human Placental Catechol-O-methyltransferase. DNA Cell Biol. 1991;10(3):181-189.

Qayyum A, Zai CC, Hirata Y, et al. The Role of the Catechol-o-methyltransferase ( COMT ) Gene Val158Met in Aggressive Behavior , A Review of Genetic Studies. Curr Neuropharmacol. 2015;13:802-814.

Kestler LJ, Mazzanti C, Ph D, et al. A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition. Am J Psychiatry. 2002;159(April):652-654.

Yeh T-K, Yeh T-C, Weng C-F, et al. Association of polymorphisms in genes involved in the dopaminergic pathway with blood pressure and uric acid levels in Chinese females. J Neural Transm. 2010;117:1371-1376. doi:10.1007/s00702-010-0492-6

Htun NC, Miyaki K, Song Y, Ikeda S, Shimbo T, Muramatsu M. Association of the Catechol- O -Methyl Transferase Gene Val158Met Polymorphism With Blood Pressure and Prevalence of Hypertension : Interaction With Dietary Energy Intake. Am J Hypertens. 2009;24(9):1022-1026. doi:10.1038/ajh.2011.93

Annerbrink K, Westberg L, Nilsson S, Rosmond R, Holm G, Eriksson E. Catechol O -methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men. Metab Clin Exp. 2008;57:708-711. doi:10.1016/j.metabol.2008.01.012

Stewart SH, Oroszi G, Randall PK, Anton RF. COMT Genotype Influences the Effect of Alcohol on Blood Pressure : Results From the COMBINE Study. Am J Hypertens. 2009;22(1):87-91. doi:10.1038/ajh.2008.321

Ge L, Wu HY, Pan SL, et al. COMT Val158Met polymorphism is associated with blood pressure and lipid levels in general families of Bama longevous area in China. Int J Clin Exp Pathol. 2015;8(11):15055-15064.

Sohani ZN, Meyre D, de Souza RJ, et al. Assessing the quality of published genetic association studies in meta-analyses: The quality of genetic studies (Q-Genie) tool. BMC Genet. 2015;16(1):1-8. doi:10.1186/s12863-015-0211-2

Lau J, Ioannidis JPA, Schmid CH. Quantitative Synthesis in Systematic Reviews. Ann Intern. 1997;127(9):820-826.

Zintzaras E, Hadjigeorgiou ÆGM. Association of paraoxonase 1 gene polymorphisms with risk of Parkinson ’ s disease : a meta-analysis. J Hum Genet. 2004;49:474-481. doi:10.1007/s10038-004-0176-x

Dersimonian R, Laird N. Meta-Analysis in Clinical Trials *. 1986;188:177-188.

WHO. High blood pressure - country experiences and effective interventions utilized across the European Region. WHO Reg Off Eur. 2013.

Chiang C, Chen C. Hypertension in the Asia-Pacific region. J Hum Hypertens. 2008;22:441-443. doi:10.1038/jhh.2008.17

Witte AV, Jansen S, Schirmacher A, Young P, Flöel A. COMT Val 158 Met polymorphism modulates cognitive effects of dietary intervention. Neurosci Aging. 2010;2(November):1-7. doi:10.3389/fnagi.2010.00146

Ittiwut1 R, Listman JB, Ittiwut C, et al. Association between polymorphisms in catechol-O- methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. Am J Med Genet B Neuropsychiatr Genet. 2011;6. doi:10.1002/ajmg.b.31205.Association

Yoshida T, Kato K, Yokoi K, et al. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. Int J Mol Med. 2009;24:233-246. doi:10.3892/ijmm

Wang Q, Li H, Beijing T, Yuan P, Li J. Soy isoflavones, CYP1A1, CYP1B1, and COMT polymorphisms, and breast cancer: A case-control study in southwestern China. DNA Cell Biol. 2010;(March 2011). doi:10.1089/dna.2010.1195

Zhang Y, Chen M, Chen J, Wu Z. Metabolic syndrome in patients taking clozapine : prevalence and influence of catechol-O-methyltransferase genotype. Psychopharmacology (Berl). 2014;231:2211-2218. doi:10.1007/s00213-013-3410-4

Antentor Othrell Hinton Jr. YH, Xia Y, Xu P, et al. Estrogen Receptor-α in the Medial Amygdala Prevents Stressinduced Elevations in Blood Pressure in Females.pdf. Hypertension. 2016;67(6):1321-1330.

Xue B, Zhang Z, Beltz TG, Guo F, Hay M, Johnson AK. Estrogen regulation of the brain renin-angiotensin system in protection against angiotensin II-induced sensitization of hypertension. Am J Physiol Circ Physiol. 2014;307(2):191-198. doi:10.1152/ajpheart.01012.2013

Contreras F, Fouillioux C, Simonovis N, Herna R, Velasco M. Dopamine , hypertension and obesity. J Hum Hypertens. 2002;16(S1):S13-S17. doi:10.1038/sj/jhh/1001334




How to Cite

Mohammed A. Merzah, & Natae , S. . (2021). CATECHOL O-METHYLTRANSFERASE VAL158/MET AND HYPERTENSION: A META-ANALYSIS. Malaysian Journal of Public Health Medicine, 21(2), 162–167.