SPATIAL ANALYSIS OF PROSTATE CANCER INCIDENCE IN IRAQ DURING 2000-2015
Prostate cancer incidence rates have evidenced a substantial increase in Iraq over the past sixteen years. Geographic variation of prostate cancer in Iraq has not been explored. We examine the geographic incidence patterns of prostate cancer in Iraq using the global index of spatial autocorrelation, Getis-Ord Gi* and Anselin Local Moran’s to detect hotspots, coldspots, and spatial outliers of prostate cancer rates. We calculated the age-adjusted incidence rates (AAIRs) according to district level for three periods (2000-2004, 2005-2009, and 2010-2015). Disease maps were produced to explore whether prostate cancer incidence clusters by district, and where hotspots and coldspots occur. Results highlight several districts of Iraq where the burden of prostate cancer incidence is especially high. In 2005-2009, the spatial autocorrelation analysis revealed a prostate cancer incidence hotspot in Al-Rissafa, Al-Manathera, Al-Kufa, Al-Hilla, Al-Hindiya, and Kerbela district. In 2010-2015, hotspots were seen in Al-Mussyab, Al-Hilla, Al-Hindiya, Al-Rissafa, Al-Adhamiya, Al-Sadir, and Daquq district. Examining spatial pattern of prostate cancer AAIRs is critical to government efforts to focus on those regions, and to understanding and targeting prostate cancer
Bray F, Ferlay J, Soerjomataram I, Siegel RL, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424.https://acsjournals.onlinelibrary.wiley.com/doi/full/10.3322/caac.21492
Fitzmaurice C, Allen C, Barber RM, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA oncology. 2017 Apr 1;3(4):524-48.https://jamanetwork.com/journals/jamaoncology/fullarticle/2588797
Rawla P. Epidemiology of prostate cancer. World J. Oncol. 2019 Apr;10(2):63.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497009/
Benke IN, Leitzmann MF, Behrens G, et al. Physical activity in relation to risk of prostate cancer: a systematic review and meta-analysis. Ann. Oncol. 2018 May 1;29(5):1154-79.https://www.annalsofoncology.org/article/S0923-7534(19)34542-9/pdf
Annual Statistical Report 2015. Planning Directorate, Ministry of Health/ Environment, Republic of Iraq 2016: 4-5. https://moh.gov.iq/upload/upfile/ar/833.pdf
Hussain RA, Habib OS. Incidence of cancer in Basrah: results of a household survey. Asian Pac J Cancer Prev. 2015;16:163-http://journal.waocp.org/article_30407_8d8c29b5eb75f6ed408b82fa0a4893c6.pdf
Al-Janabi AA, Naseer ZH, Hamody TA. Epidemiological study of cancers in Iraq-Karbala from 2008 to 2015. Int J Med Res Health Sci. 2017;6(1):79 https://www.ijmrhs.com/medical-research/epidemiological-study-of-cancers-in-iraqkarbala-from-2008-to-2015.pdf
Khoshnaw N, Mohammed HA, Abdullah DA. Patterns of cancer in Kurdistan-results of eight years cancer registration in Sulaymaniyah Province-Kurdistan-Iraq. Asian Pac J Cancer Prev. 2015;16(18):8525-31 http://journal.waocp.org/article_31772_6d6793bd5678da4f2ce86876bf5834dc.pdf
Wong DW, Lee J. Statistical analysis of geographic information with ArcView GIS and ArcGIS. Hoboken, NJ: John Wiley & Sons; 2005.
Ord JK, Getis A. Local spatial autocorrelation statistics: distributional issues and an application. Geogr. Anal. 1995 Oct;27(4):286-306. https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1538-4632.1995.tb00912.x
Anselin L. Local indicators of spatial association—LISA. Geogr. Anal. 1995;27(2): 93-115. https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1538-4632.1995.tb00338.x
Bray F, Lortet-Tieulent J, Ferlay J, et al. Prostate cancer incidence and mortality trends in 37 European countries: an overview. Eur. J. Cancer. 2010 Nov 1;46(17):3040-52.DOI:https://doi.org/10.1016/j.ejca.2010.09.013
Zorlu F, Zorlu R, Divrik RT, et al. Prostate cancer incidence in Turkey: an epidemiological study. Asian Pac J Cancer Prev. 2014 Jan 1;15(21):9125-30.http://journal.waocp.org/article_30071_c7b0667d38c475dc724db6ebdff4db27.pdf
Al-Abdin OZ, Al-Beeshi IZ. Prostate cancer in the Arab population: an overview. Saudi Med J. 2018;39(5):453.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118189/pdf/SaudiMedJ-39-453.pdf
Al-Tmemi MB. Epidemiological Study of Patients with Prostate Cancer in South of Iraq. University of Thi-Qar Journal of Science. 2014;4(3):72-6. https://www.iasj.net/iasj?func=fulltext&aId=92674
Ifere GO, Abebe F, Ananaba GA. Emergent trends in the reported incidence of prostate cancer in Nigeria. CLIN EPIDEMIOL. 2012;4:19.
Merrill RM, Morris MK. Prevalence-corrected prostate cancer incidence rates and trends. Am. J. Epidemiol. 2002;155(2):148-52.
Hennis AJ, Hambleton IR, Wu SY, et al. Prostate cancer incidence and mortality in Barbados, West Indies. Prostate Cancer. 2011;2011.
Pakzad R, Rafiemanesh H, Ghoncheh M, et al. Prostate cancer in Iran: trends in incidence and morphological and epidemiological characteristics. Asian Pac J Cancer Prev. 2016;17(2):839-43.
Li J, Djenaba JA, Soman A, Rim SH, et al. Recent trends in prostate cancer incidence by age, cancer stage, and grade, the United States, 2001–2007. Prostate cancer. 2012;2012.
Stangelberger A, Waldert M, Djavan B. Prostate cancer in elderly men. Reviews in urology. 2008;10(2):111.
Delongchamps NB, Wang CY, Chandan V, Jones RF, Threatte G, Jumbelic M, de la Roza G, Haas GP. Pathological characteristics of prostate cancer in elderly men. The J. Urol.. 2009 Sep 1;182(3):927-30.
Dasgupta P, Baade PD, Aitken JF, et al. Geographical variations in prostate cancer outcomes: a systematic review of international evidence. FRONT ONCOL. 2019 Apr 8;9:238.
Hoidy WH, Jaber FA, Al-Askiry MA. Association of CYP1A1 rs1048943 Polymorphism with Prostate Cancer in Iraqi Men Patients. Asian Pac J Cancer Prev. 2019;20(12):3839.
Khudur KM. Assessment of contributing risk factors for patients with prostate cancer in Capital of Baghdad. Kufa Journal for Nursing sciences. 2012;2(2):38-45.