A STUDY OF CLINICAL FEATURES AND LABORATORY PROFILE OF DENGUE FEVER IN OUTPATIENT SETTING
DOI:
https://doi.org/10.37268/mjphm/vol.20/no.2/art.422Keywords:
Dengue fever, Clinical, LaboratoryAbstract
Dengue fever (DF) is one of the common mosquito-borne viral diseases. It is transmitted by Aedes aegypti and Aedes albopictus.The aim to study the clinical and laboratory manifestations of serologically confirmed cases of DF in outpatient clinics.This cross-sectional study was carried out in outpatient setting. According to WHO criteria all patients above 14 years old who were suspected to have DF were tested by IgM dengue antibody test. Additionally all patients underwent history, clinical examination and investigation including complete blood count, liver function test and abdominal ultrasound. Data was analyzed using SPSS version 20.Out of 126 patients presented with acute febrile illness, 71 (56.3%) had seroreactivity for dengue IgM antibodies. Fever, headache and muscloskeletal pain were the most common clinical presentation (100%). Decreased appetite (92.9%) , retro-orbital pain (78.8%) and dizziness(64.7%) were the next common symptoms. 29(40.8%) had hepatomegally, 11 (15.4%) had splenomegally.Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were observed in 58(81.6%) and 53(74.6%) respectively. Lastly; Fever associated with headache, retro-orbital pain, along with thrombocytopenia and elevated liver transaminases should prompt a clinician on the possibility of DF. Increased community awareness and vector control measures need to be strengthened to reduce the burden of dengue cases.
References
World Health Organization. Media center: Dengue and Severe Dengue. http://www.who.int/mediacentre/factsheets/fs117/en/
Ten threats to global health in 2019. World Health Organization. Available at https://www.who.int/emergencies/ten-threats-to-global-health-in-2019. 2019; Accessed: Feb 2, 2019.
Bhatt S, Gething PW, Brady OJ, et al., The global distribution and burden of dengue.Nature. 2013 Apr25;496(7446):504-7.
Fakeeh M, Zaki AM. Virologic and serologic surveillance for dengue fever in Jeddah, Saudi Arabia, 1994–1999.Am J Trop Med Hyg, 65 (2001), pp. 764-767.
Ministry of Health, Department of StatisticsHealth statistical year book 2009 Saudi Ministry of Health, Riyadh, KSA (2010) ISSN: 1319-3228.
Alhaeli A, Bahkali S, Ali A, Househ MS, ElMetwallyAA.The epidemiology of Dengue fever in Saudi Arabia: A systematic review. J Infect Public Health. 2016 Mar-Apr;9(2):117-24.
Ayyub M, Khazindar AM, Lubbad EH, Barlas S, Alfi AY, Al-Ukayli S.Characteristics of dengue fever in a large public hospital, Jeddah, Saudi Arabia.J Ayub Med Coll Abbottabad, 18 (2006), pp. 9-13.
Al-Azraqi TA, El Mekki AA, Mahfouz AA.Seroprevalence of dengue virus infection in Aseer and Jizan regions, Southwestern Saudi Arabia. Trans R Soc Trop Med Hyg. 2013 Jun;107(6):368-71.
Khan NA, Azhar EI, El-Fiky S, et al.Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia. Acta Trop. 2008 Jan;105(1):39-44.
Khormi HM, Kumar L. Assessing the risk for dengue fever based on socioeconomic and environmental variables in a geographical information system. Geospat Health. 2012 May;6(2):171-6.
Khormi HM, Kumar L. The importance of appropriate tem-poral and spatial scales for dengue fever control andmanagement. Sci Total Environ 2012;430:144—9.
A.A. ElBadry, H.A. ElBeshbishy, K.H. Al-Ali, A.M. Al-Hejin, W.S.M. El Sayed. Molecular and seroprevalence of imported dengue virus infection in Al-Madinah, Saudi Arabia. Comp Clin Pathol, 23 (4) (2014), pp. 861-868.
Srikiatkhachorn A, Gibbons RV, Green S, Libraty DH, Thomas SJ, et al. Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. Clin Infect Dis 2010; 50:1135–1143.
Mohan D K, Shiddappa, Dhananjaya M. A Study of Clinical Profile of Dengue Fever in a Tertiary Care Teaching Hospital. Sch J App Med Sci 2013; 1:280-282.
Agarwal R, Kapoor S, Nagar R, Misra A, Tandon R, Mathur A, et al. A clinical study of the patients with dengue hemorrhagic fever during the epidemic of 1996 at Lucknow, India. Southeast Asian J Trop Med Public Health 1999;30:735‑40.
Alzahrani AG, Al Mazroa MA, Alrabeah AM, Ibrahim AM,Mokdad AH, Memish ZA. Geographical distribution and spatio-temporal patterns of dengue cases in Jeddah Governorate from 2006—2008. Trans R Soc Trop Med Hyg2013;107:23—9.
Horta MA, Bruniera R, Ker F, Catita C, Ferreira AP. Temporal relationship between environmental factors and the occurrence of dengue fever. Int J Environ Health Res 2014:1—11.
García-Gutiérrez MD, Romero-Zepeda H, Salvador Romero-Márquez R. Risk factors associated to the epidemic outbreak of dengue virus infection. Rev Med Inst Mex Seguro Soc2013;51:628—34.
Raza FA, Rehman SU, Khalid R, Ahmad J, Ashraf S, IqbalM, et al. Demographic and clinico-epidemiological features of dengue Fever in Faisalabad, Pakistan. PLOS ONE2014;9:e89868.
Ahmed MM. Clinical profile of dengue fever infection in KingAbdul Aziz University Hospital Saudi Arabia. J Infect DevCountries 2010;4:503—10.
Nandini, C., Mainak, M., Sinjon, G., Manas, M., Chiranjib D, Kartik P. An observational study of dengue fever in a tertiary care hospital of Eastern India. J. Assoc. Physicians India, 62: 12–5.
Awasthi S., Singh V., Kumar S., Kumar A., and Dutta S. The changing clinical spectrum of Dengue fever in the 2009 epidemic in north India: a tertiary teaching hospital based study,” Journal of Clinical and Diagnostic Research,vol. 6, no. 6,pp. 999–1002, 2012.
Horvath, R., Mcbride WJH, Hanna JN. Clinical features of hospitalized patients during dengue 3 epidemic in Far North Queensland 1997-99. Dengue Bulletin. 1999; 23:24- 29.
Mohamed K,Kalavathi P, Mehul R, Karthik M,Asfiya A,Kumaraswamy R. A study of clinical and laboratory profile of dengue fever in tertiary care hospital in central Karnataka, India. Glob. J. Med. Res. B: Pharma Drug Discov. Toxicol. Med., 14(5).
Deshwal, R., Qureshi, M.I., Singh, R. Clinical and Laboratory Profile of Dengue Fever. J Assoc Physicians India. 2015 Dec;63(12):30-32.
Lepakshi, G., N. Padmaja, Rafiq Pasha, H. A study of clinical profile of Adult patients with dengue fever. Indian J. Appl. Res., 2015,5:820-823.
Munde, D, Shetkar U. Clinical Features and Haematological Profile of Dengue Fever. Indian Journal of Applied Research. 2013; 3:131-132.
Ragini S, Singh P., Niaz A. A Study of Clinical and Laboratory profile of dengue fever in a tertiary care centre of Uttarakhand, India. Int. J. Res Med Sci. 2014; 2:160-163.
Karoli R, Fatima J, Siddiqi Z, Kazmi KI, Sultania AR.Clinical profile of dengue infection at a teaching hospital in North India. J Infect Dev Ctries. 2012 Jul 23;6(7):551-4.
Itoda, I., Masuda, G, Suganuma A et al. Clinical features of 62 importedcases of dengue fever in Japan. Am J Trop Med Hyg 2006; 75 (3): 470-4.
Rahim, M.A., Sikder MS. Clinicopathologic manifestations and outcome of dengue fever and dengue haemorrhagic fever. Bangladesh Med Res Counc Bull. 2005 Apr;31(1):36-45.
Mandal SK, Ganguly J, Koelina Sil et al.Clinical profiles of dengue fever in a teaching hospital of eastern india. Nat J Med Res 2013; 3:173-176.
Rashmi KS, Jagdeesh, Ravikumar KL, Giridhar UP, Arun KR. Serological markers prevalence and trend of probable dengue infection at a tertiary care hospital in Banglore. J Evolution of Medical and Dental Sciences. 2013;2(36):6968-77.
Mena Lora AJ, Fernandez J, Morales A, Soto Y, Feris-Iglesias J, Brito MO. Disease severity and mortality caused by dengue in a Dominican pediatric population. Am J Trop Med Hyg. 2014 Jan;90(1):169-72.
Munde, D.D., Shetkar U B. Clinical Features and Haematological Profile of Dengue Fever. Indian Journal of Applied Research. 2013; 3:131-132.
Ageep AK, Malik AA, Elkarsani MS. Clinical presentations and laboratory findings in suspected cases of dengue virus. Saudi Med J. 2006 Nov;27(11):1711-3.
De Macedo FC, Nicol AF, Cooper LD, Yearsley M, Pires AR, Nuovo GJ. Histologic, viral, and molecular correlates of dengue fever infection of the liver using highly sensitive immunohistochemistry. Diagn Mol Pathol. 2006 Dec. 15(4):223-8.
Chatterjee N, Mukhopadhyay M, Ghosh S, Mondol M, Das C, Patar K. An observational study of dengue fever in a tertiary care hospital of Eastern India. J Associ Physicians of India. 2014;62(3):224-7.
Chhotala YH, Suva CM. A study of clinical profile of dengue fever in a tertiary care hospital of Jamnagar, Gujarat, India. Int J Res Med Sci. 2016;4(10):4500-4.
