THE RELATIONSHIP OF BIOCHEMICAL MARKERS AND COAGULATION PROFILES WITH THE SURVIVAL STATUS AMONG COVID-19 PATIENTS

Authors

  • Nurul Farah Syahidah Mohamad Samuri Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus 47000 Sungai Buloh Selangor, Malaysia
  • Noor Alicezah Mohd Kasim Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus 47000 Sungai Buloh Selangor, Malaysia
  • Mohamad Rodi Isa Department of Public Health Medicine, Faculty of Medicine, Universiti Teknologi Mara (UiTM) Sungai Buloh Campus 47000 Sungai Buloh Selangor, Malaysia
  • Madyhah Abdul Monir Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus 47000 Sungai Buloh Selangor, Malaysia
  • Marshima Mohd Rosli Institute of Pathology, Laboratory and Forensic Medicine (I-PPerForM) Universiti Teknologi MARA Sungai Buloh Campus 47000 Sungai Buloh Selangor, Malaysia
  • Nur Amalina Yusoff Department of Pathology Hospital Sungai Buloh, Jalan Hospital, 47000 Sungai Buloh, Selangor
  • Sharifah Khairul Atikah Department of Pathology Hospital Sungai Buloh, Jalan Hospital, 47000 Sungai Buloh, Selangor

Keywords:

biochemical marker, COVID-19, coronavirus, Malaysia, procalcitonin, biochemical marker, COVID-19, coronavirus, Malaysia, procalcitonin, survival status

Abstract

The Coronavirus Disease of 2019 (COVID-19) is an imminent threat to world health, and effective management of COVID-19 patients is needed. Biochemical markers and coagulation profiles are required for medical intervention and prediction of morbidity and mortality. This study aims to determine the relationship between biochemical markers and coagulation profiles with the survival status among COVID-19 patients. A cross-sectional study using secondary data was conducted among 470 COVID-19 patients admitted to Hospital Sungai Buloh from April 2021 to July 2021. The biomarkers include C-reactive protein (CRP), ferritin, procalcitonin (PCT), lactate dehydrogenase (LDH), D-dimer, high-sensitivity troponin I (hs-Trop I), creatine kinase (CK), sodium, potassium, urea, creatinine, alanine transaminase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, activated partial thromboplastin time (APTT) and prothrombin time (PT) along with survival status were extracted from the hospital electronic medical records. The relationship between biomarkers with the survival status among COVID-19 patients was analysed using simple and multiple logistic regression. The results showed an increased odd of mortality in deceased patients, particularly in PCT with an odds ratio (OR) of 1.028 (95%CI: 1.001, 1.055), LDH with an OR of 1.002 (95%CI: 1.001,1.003), and urea with an OR of 1.070 (95%CI: 1.034,1.107) compared to survivors. All three biomarkers give 98.7% sensitivity and 13.0% specificity with the area under the curve (AUC) of 0.762 (95%CI: 0.705, 0.820). In summary, our research underscores a significant correlation between the mortality risk of COVID-19 patients and increased PCT, LDH, and urea.

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Published

2024-06-03

How to Cite

Mohamad Samuri , N. F. S., Mohd Kasim, N. A., Isa, M. R., Abdul Monir, M., Mohd Rosli , M., Yusoff, N. A., & Khairul Atikah, S. (2024). THE RELATIONSHIP OF BIOCHEMICAL MARKERS AND COAGULATION PROFILES WITH THE SURVIVAL STATUS AMONG COVID-19 PATIENTS. Malaysian Journal of Public Health Medicine, 24(1), 28–37. Retrieved from https://mjphm.org/index.php/mjphm/article/view/2289