TREATMENT PATTERN AND COST-EFFECTIVENESS ANALYSIS OF ORAL HYPOGLYCEMICS FOR TYPE 2 DIABETES MELLITUS OUTPATIENTS AT REGIONAL GENERAL HOSPITAL, INDONESIA
Type 2 diabetes mellitus (DM) has become a major problem, with most cases appearing as a degenerative disease that is almost uncontrollable using single or combined oral therapy. Therefore, this study aims to examine the sociodemographics, treatment pattern, and cost-effectiveness analysis of oral hypoglycemics for type 2 DM outpatients at Cempaka Putih Regional General Hospital, Central Jakarta, Indonesia. This descriptive study was conducted within six months using a cross sectional design. The inclusion criteria were 18 years old type 2 DM patients receiving outpatient treatment, patients with a primary diagnosis of type 2 DM without complications, health insurance (BPJS), good medical records, and the pharmacoeconomic values approach with the Cost-Effectiveness Analysis (CEA) method, which is a review from hospital and healthcare perspective. A total of 79 patients participated and the analysis was carried out using ACER and ICER calculations of cost-effective therapy in each group. The results showed that the most cost-effective therapy for the oral group is a biguanide with metformin 500 mg and an ACER value of IDR19,196, 2 combination therapies namely Glibenclamide and metformin with ACER of IDR39,160, and the 3 combinations of metformin + glimepiride + acarbose IDR156,761. The lowest calculation of ICER value was between monotherapy metformin IDR16,896 and oral combination of metformin + glibenclamide IDR19,883. This indicated that pharmacoeconomic data allow users to make more rational decisions in selecting therapy, treatment, as well as clinical and administrative decision-makers, including physicians, pharmacists, formulary committee members, and administrators for insurance companies.
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