• Thanom Namwong Faculty of Public Health, Mahasarakham University, 44150, Mahasarakham, Thailand
  • Choosak Nithikathkul Tropical and Parasitic Disease Research Unit, Faculty of Medicine, Mahasarakham University, 44000, Mahasarakham, Thailand
  • Vorapoj Promsatayaprot Faculty of Public Health, Mahasarakham University, 44150, Mahasarakham, Thailand
  • Sumattana Glangkarn Faculty of Public Health, Mahasarakham University, 44150, Mahasarakham, Thailand
Keywords: Hepatitis B virus, Seroprevalence, Predictive model


This study investigated the prevalence of Hepatitis B virus (HBV) and identified a predictive statistical model for the HBV exposure among people in the community, Yasothon, Thailand. A cross-sectional study was performed on participants over 26 years old and living in Muang district, Yasothon province, Thailand. The research was conducted from July to August 2019. All 1,258 participants were verbally screened. Four hundred and fifty nine people were the risk group and tested for HBsAg, and 18 cases were positive for HBsAg (3.9% [95%CI 3.5-4.4]). For the predictive model, the HBV exposure connected with sex, marital status, alcohol, smoking, and knowledge. The area under the receiver operating characteristics (ROC) curve was 61.8 % (95%CI, 58.6 to 65.0). At cut-off-point -0.66, the sensitivity, specificity and accuracy were 72.6%, 42.4 % and 53.4%, respectively. HBV infection was a serious health problem, it can cause cirrhosis and liver cancer in the future. The predictive model of five variables can predict risk exposure of HBV which may had other relevant factors. Verbal screening by questionnaire to classify HBsAg risk group can lower the implement cost.


World Health Organization(WHO) [Internet]. Hepatitis B/Key facts [cited 2020 July 27]. Available from:

Yanwetsakun P, Siriwongrangsan P, Sutthiwat SC, Tangprasertsuk S. Prevention strategy of hepatitis B virus of Thailand 2017-2021; JS printing: 2017.

Leroi C, Adam P, Khamduang W, Kawilapat S, Ngo-Giang-Huong N, Ongwandee S, et al. Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis. Int J Infect Dis 2016; 51: 36–43.

Silarak K, Namwong T. An Evaluation of Hepatitis B viral surveillance, Yasothon province, Thailand, January 2014–December 2016. Weekly Epidemiological Surveillance Report 2017; 48(49): 769-76.

World Health Organization (WHO) [Internet]. Global Health Sector Strategy on Viral hepatitis 2016–2021. Geneva, Switzerland: the WHO Document Production Services 2016. [cited 2019 Feb 20]. Available from:

Cochran WG. Sampling techniques. 3rd ed. Biostatistics. New York: John Wiley & Son; 1977.

Best JW. Research in Education. New York: Prentice-Hall, Englewood Cliffs; 1977.

Hosmer DW, Lemashow S. Applied Logistic Regression. 2nd ed. New York: A Wiley Interscience Publication; 2000.

Ataei B, Alavian SM, Shahriari-Fard F, Rabiei A A, Safaei A, Rabiei A. A case-control study of risk factors for hepatitis B infection: A regional report among Isfahanian adults. J Res Med Sci 2019; 24: 22.

Pereira VRZB, Wolf JM, da Silva-Luz CM, Stumm GZ, da Rocha-Boeira T, Galvan J, Simon D, Lunge VR. Risk factors for hepatitis B transmission in South Brazil. Mem Inst Oswaldo Cruz, Rio de Janeiro 2017; 112(8): 544-50.

Bauer-Staeb C, Jorgensen L, Lewis G, Dalman C, Osborn DPJ, Hayes JF. Prevalence and risk factors for HIV, hepatitis B, and hepatitis C in people with severe mental illness: a total population study of Sweden. The Lancet Psychiatry 2017; 4(9): 685-93.

Zhou Y, Wan Y, Ye ZW, He Z, Liu Q, Shi Y. How Hepatitis B virus causes cirrhosis and liver cancer. Medical Hypotheses 2017; 108: 52-53.

Suh JK, Lee J, Lee J-H, Shin S, Tchoe Hj, Kwon J-W. Risk factors for developing liver cancer in people with and without liver disease. PLoS ONE 2018; 13(10): 1-13.

Tantai N, Werayingyong P, Leelahavarong P, Teerawattananon Y. Cost-utility analysis of screening for hepatitis B viral infection in Thailand. Health Systems Research Institute (HSRI) journal 2013; 7(4): 440-51.

Kao JH. Hepatitis B vaccination and prevention of hepatocellular carcinoma. Best Practice and Research: Clinical Gastroenterology 2015; 29(6): 907-17.

Torre GL, Saulle R. Risk factors from HBV infection among blood donors: A systematic review. Asian Pac J Trop Biomed 2016; 6(4): 344-9.

Frew G, Mc George E, Grant S, Wildt G. Hepatitis B: A cross-sectional survey of knowledge, attitudes and practices amongst backpackers in Thailand. Travel Medicine and Infectious Disease 2017; 15: 57-62.

Xaydalasouk K, Strobel M, Buisson Y, Black AP, Muller CP. Seroprevalence and risk factors of hepatitis B and C virus infections in female workers of Lao garment factories. PLoS ONE 2018; 13(7): 1-8.

Rajamoorthy Y, Taib NM, Mudatsir M, Harapan H, Wagner AL, Munusamy S, Rahim KA, Radam A. Risk behaviours related to hepatitis B virus infection among adults in Malaysia: A cross-sectional household survey. Clinical Epidemiology and Global Health 2020; 8: 76-82.

Greiner M, Pfeiffer D, Smith RD. Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests. Preventive Veterinary Medicine 2000; 45: 23-41.

How to Cite
Thanom Namwong, Choosak Nithikathkul, Vorapoj Promsatayaprot, & Sumattana Glangkarn. (2020). SERO-PREVALENCE AND PREDICTIVE STATISTICAL MODEL FOR THE HEPATITIS B VIRUS EXPOSURE AMONG PEOPLE IN COMMUNITY, YASOTHON, THAILAND. Malaysian Journal of Public Health Medicine, 20(3), 35-41.