• Maytham Salim Al-Nasrawii Community Health Department, Technical Institute of Karbala, AL-Furat Al-Awsat Technical University, Iraq https://orcid.org/0000-0001-8807-9785
  • Balqees Sadoon Jasim Community Health Department, Technical Institute of Karbala, AL-Furat Al-Awsat Technical University, Iraq https://orcid.org/0000-0002-1837-1956
  • Salim Hussein Hassan Community Health Department, Technical Institute of Karbala, AL-Furat Al-Awsat Technical University, Iraq
Keywords: Diabetic Nephropathy, Cystatin C, Serum Creatinine, Type 2 DM


The critical micro-vascular complications of diabetes ultimately result in renal dysfunction known as diabetic nephropathy (DN). Measurement of glomerular filtration rate (GFR) is considered to be an important parameter in renal function assessment, evaluating GFR by Creatinine level. Recently, Cystatin C is used as a substitute indicator in several studies to assess diabetic nephropathy. This work was conceived to determine whether serum cystatinC would replace serum creatinine (Scr) in patients with type2 diabetes for early evaluation of nephropathy. A Case-Control Study was enrolled on 30 Patients with diabetic and 30 apparently healthy as control, aged between 25 - 83 years. Levels of serum cystatine C and serum Creatinine were calculated for both groups. Serum Creatinine, as well as serum cystatin C levels, was significant relationship with diabetic pt. in compared to non-diabetic individuals. ROC analysis noted the cystatinC was more predict indicator in diagnosed Diabetic Nephropathy (DNP) from Serum Creatinine level. In Type 2 diabetics, CystatinC is a good marker for uncontrolled diabetic nephropathy relative to serum creatinine.


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How to Cite
Al-Nasrawii, M. S., Sadoon Jasim, B., & Hussein Hassan, S. (2020). A COMPARATIVE ASSESSMENT OF SERUM CREATININE AND CYSTATIN C AS A SIGNIFICANCE OF NEPHROPATHY IN DIABETIC PATIENTS. Malaysian Journal of Public Health Medicine, 20(3), 189-194. https://doi.org/10.37268/mjphm/vol.20/no.3/art.527