• Hairul Izwan Abdul Rahman Surveillance Complex, Kinta District Health Office, c/o Jelapang Health Clinic, Jalan Jelapang, 30020 Ipoh, Perak, Malaysia
  • Nor Aida Sanusi Pharmaceutical Services Division, Perak State Health Department, c/o Hospital Bahagia Ulu Kinta, 31250 Tanjung Rambutan, Perak, Malaysia
  • Muhammad Syafik Ikhwan Salleh Pharmacy Unit, Taiping Hospital, Jalan Taming Sari, 34000 Taiping, Perak, Malaysia
  • Ng Yoon Yeen Medical Division, Perak State Health Department, Jalan Panglima Bukit Gantang Wahab, 30000 Ipoh, Perak, Malaysia
  • Ismail Ali Mohd Jobran Pharmacy Unit, Batang Padang District Health Office, Jalan Temoh, 35000 Tapah, Perak, Malaysia
  • Nor Suhailah Mohd Hasan Pharmacy Unit, Kuala Kangsar District Health Office, Jalan Sultan Idris Shah 1, 33000 Kuala Kangsar, Perak, Malaysia
  • Siti Nur Umi Aminah Zainal Bahri Pharmacy Unit, Perak Tengah District Health Office, Jalan Ipoh-Lumut, Bandar Seri Iskandar, 32610 Seri Iskandar, Perak, Malaysia
Keywords: Methadone, Cox regression, HIV seroconversion, survival analysis


In 2005, Ministry of Health introduced the Needle Syringe Exchange Program (NSEP) and Methadone Maintenance Therapy (MMT) program as a part of Harm Reduction program to combat HIV infection in Malaysia among people who inject drug (PWIDs). Expenditures were estimated approximately RM10 millions per year to establish and sustain the NSEP and MMT centres. This study examined the impact of MMT program on preventing HIV seroconversion among registered MMT clients that are people who inject drug (PWIDs), and to identify other predictors of HIV seroconversion among this group.  This was a retrospective cohort study done in the state of Perak involving a total of 212 randomly selected MMT clients registered between 2008-2017 in 6 clinics. This study looks at data collected from the last ten-year cohort from baseline to follow-up. A questionnaire was used to obtain socio-demographic data, sexual and drugs abuse history. Test results for HIV were obtained from medical records. Cox regression analysis was performed to examine factors associated with seroconversion and Kaplan-Meier analysis to estimate HIV survival time. This study displayed that both Methadone take home supply (HR 10.4, 95% CI: 1.6 – 68.8) and unprotected sexual practice (HR 5.9, 95%CI: 1.1 – 31.5) shown higher risks of HIV seroconversion compared to DOTS and condom practice among MMT clients respectively. Mean survival for HIV seroconversion among MMT clients was 104.44 (95%CI: 101.85 – 107.04) months.  This study provides reliable evidence that MMT program markedly reduces incidence of HIV infection among people who inject drug (PWIDs).


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How to Cite
Hairul Izwan Abdul Rahman, Nor Aida Sanusi, Muhammad Syafik Ikhwan Salleh, Ng Yoon Yeen, Ismail Ali Mohd Jobran, Nor Suhailah Mohd Hasan, & Siti Nur Umi Aminah Zainal Bahri. (2019). IMPACT OF METHADONE MAINTENANCE THERAPY ON HIV INCIDENCE IN PERAK, 2008 - 2017: A COX REGRESSION ANALYSIS. Malaysian Journal of Public Health Medicine, 19(1), 75-83.